Evaluation of Radio-Protective Effects of N-Acetylcysteine on Radiation-Induced Lethality in Mice

Authors

  • ashkan salajegheh Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  • mehdi hoseini Medical Physics Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mina Nouri Department of Radiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
  • Yaser Masoumi-Ardakani Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Abstract:

Introduction It has long been known that ionizing radiation can lead to detrimental effects in normal cells. In this light, Radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. This study aimed to evaluate the radio-protective effect of N-acetylcysteineagainst radiation-induced mortality in male mice. Materials and Methods 52 healthy male mice were divided into four groups including NAC before irradiation (1), irradiation (2), NAC after irradiation (3) NAC before irradiation (4) and control. Three groups were treated orally with 100 mg/ kg of NAC. Gamma irradiation was performed at 8 Gy using a Co-60 machine. Kaplan-Meier method and the log-rank test were performed, using SPSS version 16. The significance level was considered to be 0.05. Results The statistical analysis revealed a significant difference between the test and control groups (P

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Journal title

volume 14  issue 1

pages  53- 59

publication date 2017-03-01

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